Working Paper
Authors
- Corinna Schindler
University of Michigan–Ann Arbor ,
- Alistair Richardson University of Michigan ,
- Trenton Vogel University of Michigan–Ann Arbor ,
- Emily Traficante University of Michigan–Ann Arbor ,
- Kason Glover University of Michigan–Ann Arbor
Abstract
A new, twelve-step approach towards the meroterpenoid cochlearol B is reported. This strategy takes advantage of
a palladium-catalyzed Catellani reaction of a complex chromenyl triflate and a subsequent visible light-mediated [2+2]-cycloaddition to form the central bicyclo[3.2.0]heptane core of cochlearol B. Notably, careful selection and tuning of the photocycloaddition precursor proved crucial to differentiate between cyclopropanation reactions, [4+2] cycloadditions, and selective [2+2]-photocycloadditions.
Content
