Novel Quinolizine AIE System: Visualization of Molecular Motion and Elaborate Tailoring for Biological Application

27 December 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Molecular motions are ubiquitous in nature and they immutably play intrinsic roles in all actions. However, exploring appropriate models to decipher molecular motions is an extremely important but very challenging task for researchers. Considering aggregation-induced emission (AIE) luminogens possess their unique merits to visualize molecular motions, it is particularly fascinating to construct new AIE systems as model to study molecular motion. Herein, a novel quinolizine (QLZ) AIE system was constructed based on the restriction intramolecular vibration mechanism. It was demonstrated that QLZ could act as an ideal model to visualize single-molecule motion and macroscopic molecular motion via fluorescence change. Additionally, further elaborate tailoring of this impressive core achieved highly efficient reactive oxygen species production and realized fluorescence imaging-guided photodynamic therapy applications, which confirms the great application potential of this new AIE-active QLZ core. Therefore, this work not only provides an ideal model to visualize molecular motion but also opens a new way for the application of AIEgens.


molecular motion
aggregation-induced emission
restriction of intramolecular vibration
photodynamic therapy

Supplementary materials

Supporting Information
Materials and methods, synthesis and characterizations and supporting figures


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