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Conversion of carboxylic acids to amides under the action of tantalum(V) chloride

29 November 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

It was found that the reaction of aliphatic carboxylic acids with secondary amines under the action of tantalum (V) chloride leads to the selective formation of carboxamides. N,N-Diethyladamantane-1-carboxamide were synthesized with a yield of 73% as well.

Keywords

carboxylic acids
carboxamides
tantalum (V) chloride
secondary amines
N
N-Diethyladamantane-1-carboxamide

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Version History

Nov 29, 2021 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-kq32x
D O I: 10.26434/chemrxiv-2021-kq32x [opens in a new tab]

Funding

Russian Science Foundation
19-73-10113

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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