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A Practical and Economical Route to (S)-Glycidyl Pivalate

17 November 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Keywords

Tuberculosis
API
Pretomanid
Epichlorohydrin
Supply centered synthesis

Supplementary materials

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Title
A Practical and Economical Route to (S)-Glycidyl Pivalate
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Now Published

A Practical and Economical Route to (S)-Glycidyl Pivalate [opens in a new tab]
Flavio S. P. Cardoso, David R. Snead, Jeffrey M. Noble, Le Chang, Dan Chen, Binglin Wang, Raymond N. Dominey, Daniel W. Cook, Justina M. Burns, Rodger W. Stringham journal article
SynOpen , Volume 06, Issue 04
Online publication date: Oct 19, 2022

Version History

Nov 17, 2021 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-rvrqv
D O I: 10.26434/chemrxiv-2021-rvrqv [opens in a new tab]

Funding

Bill and Melinda Gates Foundation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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