Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

A Practical and Economical Route to (S)-Glycidyl Pivalate

17 November 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Keywords

Tuberculosis
API
Pretomanid
Epichlorohydrin
Supply centered synthesis

Supplementary materials

Title
Description
Actions
Title
A Practical and Economical Route to (S)-Glycidyl Pivalate
Description
SUPPORTING INFORMATION
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

A Practical and Economical Route to (S)-Glycidyl Pivalate [opens in a new tab]
Flavio S. P. Cardoso, David R. Snead, Jeffrey M. Noble, Le Chang, Dan Chen, Binglin Wang, Raymond N. Dominey, Daniel W. Cook, Justina M. Burns, Rodger W. Stringham journal article
SynOpen , Volume 06, Issue 04
Online publication date: Oct 19, 2022

Version History

Nov 17, 2021 Version 1

Metrics

889
438
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-rvrqv
D O I: 10.26434/chemrxiv-2021-rvrqv [opens in a new tab]

Funding

Bill and Melinda Gates Foundation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Share