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A Practical and Economical Route to (S)-Glycidyl Pivalate

Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Content

Supplementary material

A Practical and Economical Route to (S)-Glycidyl Pivalate
SUPPORTING INFORMATION

Version History

Nov 17, 2021 Version 1

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License

CC logo BY logo
The content is available under CC BY 4.0 License CreativeCommons.org [opens in a new tab]

DOI

10.26434/chemrxiv-2021-rvrqv
D O I: 10.26434/chemrxiv-2021-rvrqv [opens in a new tab]

Funding

Bill and Melinda Gates Foundation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Keywords

Tuberculosis
API
Pretomanid
Epichlorohydrin
Supply centered synthesis

Publication

This content is an early or alternative research output and has not been peer-reviewed at the time of posting.