A Practical and Economical Route to (S)-Glycidyl Pivalate

Jeffrey M. Noble; Le Chang; Dan Chen; Binglin Wang; Raymond N. Dominey; Daniel W. Cook; Justina M. Burns; Rodger W. Stringham; Flavio S. P. Cardoso; David R. Snead

doi:10.26434/chemrxiv-2021-rvrqv

Organic Chemistry

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A Practical and Economical Route to (S)-Glycidyl Pivalate

Working Paper

Jeffrey M. Noble Virginia Commonwealth University ,
Le Chang WuXi AppTec (Wuhan) Co. Ltd. ,
Dan Chen WuXi AppTec (Wuhan) Co. Ltd. ,
Binglin Wang WuXi AppTec (Wuhan) Co. Ltd. ,
Raymond N. Dominey University of Richmond ,
Daniel W. Cook Virginia Commonwealth University ,
Justina M. Burns Virginia Commonwealth University ,
Rodger W. Stringham Virginia Commonwealth University ,
Flavio S. P. Cardoso Virginia Commonwealth University ,
David R. Snead Virginia Commonwealth University

Abstract

An efficient method to prepare enantiopure (S)-glycidyl pivalate from (R)-epichlorohydrin and pivalic acid is reported. This work provides an alternative to the synthesis of this important building block from readily available and inexpensive materials.

Content

Thumbnail image of 2021_11_16 CISO_Manuscript.pdf

Supplementary material

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A Practical and Economical Route to (S)-Glycidyl Pivalate

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Nov 17, 2021 Version 1

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The content is available under CC BY 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv-2021-rvrqv

Funding

Bill and Melinda Gates Foundation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

Keywords

Tuberculosis

API

Pretomanid

Epichlorohydrin

Supply centered synthesis

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This content is an early or alternative research output and has not been peer-reviewed at the time of posting.

A Practical and Economical Route to (S)-Glycidyl Pivalate

Authors

Abstract

Content

Supplementary material

Version History

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License

DOI

Funding

Author’s competing interest statement

Ethics

Keywords

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