Modular allylation of C(sp3)−H bonds by combining decatungstate photocatalysis and HWE olefination in flow

09 November 2021, Version 1

Abstract

The late-stage introduction of allyl groups provides an opportunity to synthetic organic chemists for subsequent diversification, providing rapid access to new chemical space. Here, we report the development of a modular synthetic sequence for the allylation of strong aliphatic C(sp3)–H bonds. Our sequence features the merger of two distinct steps to accomplish this goal, including a photocatalytic Hydrogen Atom Transfer and an ensuing Horner-Wadsworth-Emmons reaction. This practical protocol enables the modular and scalable allylation of valuable building blocks and medicinally relevant molecules.

Content

Supplementary materials

Supporting Information
Experimental details, reaction optimization and spectroscopic analysis

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