Difluoroalkylation of tertiary amides and lactams by an iridium-catalyzed reductive Reformatsky reaction

05 November 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The synthesis of medicinally relevant α-difluoroalkylated amines by an iridium-catalyzed reductive alkylation of tertiary amides and lactams with difluoro-Reformatsky reagents, is described. This report features the introduction of various geminal difluoro-acetates and -acetamides as well as late stage derivatization of APIs, gram scale synthesis and downstream functionalizations.

Keywords

difluoroalkylation
tertiary amides
Reformatsky
iridium
C-C coupling

Supplementary materials

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Supporting information
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Full optimization details, synthesis and characterization of starting materials and products, NMR spectra of unknown compounds.
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