Azetidines are of particular interest in medicinal chemistry for their favorable properties, including increased resistance to oxidative metabolism and lower lipophilicity. The recent development of [2+2] reactions has significantly benefitted the previously limited methods for azetidine synthesis, but access to more complex architectures still requires further development. Herein we report a visible-light enabled intramolecular [2+2] cycloaddition to access tricyclic azetidines with 3D complex structures and high levels of saturation.
Intramolecular, Visible Light-Mediated Aza Paternò-Büchi Reactions of Unactivated Alkenes
19 October 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.