Intramolecular, Visible Light-Mediated Aza Paternò-Büchi Reactions of Unactivated Alkenes

19 October 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Azetidines are of particular interest in medicinal chemistry for their favorable properties, including increased resistance to oxidative metabolism and lower lipophilicity. The recent development of [2+2] reactions has significantly benefitted the previously limited methods for azetidine synthesis, but access to more complex architectures still requires further development. Herein we report a visible-light enabled intramolecular [2+2] cycloaddition to access tricyclic azetidines with 3D complex structures and high levels of saturation.


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