Organic Chemistry

A selenium-based cysteine surrogate for protein chemical synthesis

Authors

Abstract

We provide in this protocol detailed procedures for the synthesis of SetCys cysteine surrogate and its use for chemical synthesis of proteins through the redox-controlled assembly of three peptide segments in one-pot.

Content

Thumbnail image of MIMB_SetCys_9.pdf

Supplementary material

Thumbnail image of NMR data.zip
NMR data
This compressed folder contains raw NMR data (FID files) for key selenated compounds, for comparison.