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Abstract
The arrangement of hydrogen bond donors around a central lipophilic scaffold has proven a successful strategy in the development of potent chloride transporters. In this work, we revisit an acridinone 1,9-bis(thio)urea motif which had previously shown promise as an anion sensor and expand the series of compounds by appending a variety of electron-withdrawing groups to the peripheral phenyl moieties. High levels of activity were achieved by the most effective compounds in the series, which facilitated strictly electroneutral transport.
Supplementary materials
Title
Electronic supplementary information
Description
Table of Contents Pages
Characterisation Data S2−S53
Single Crystal X-ray Diffraction S54−S55
1H NMR Titration Anion Binding Studies S56−S71
Chloride/Nitrate Exchange ISE Assay S72−S77
ISE Cationophore Coupled Assay S78−S82
HPTS NMDG-Cl Assay S83−S88
Voltage-Dependent Studies S89−S95
HPTS Mechanistic Studies S96−S101
HPTS Anion Selectivity Assay S102−S107
Molecular Modelling S108
References S109
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