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An evaluation of palladium-based catalysts for the base-free borylation of alkenyl carboxylates

26 August 2021, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Synthesis of organoboron derivatives is a key application of catalytic cross-coupling, with the Pd-catalyzed Miyaura borylation among the most versatile methods available. We have evaluated several Pd-based systems for borylation of alkenyl acetates and pivalates, with the optimal system heavily dependant on the substrate structure.

Keywords

palladium
catalysis
boron
C-O activation
cross-coupling

Supplementary materials

Title
Description
Actions
Title
An evaluation of palladium-based catalysts for the base-free borylation of alkenyl carboxylates
Description
Supporting information: experimental procedures and spectroscopic data.
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Version History

Aug 26, 2021 Version 2

Version Notes

Updated information on protodeborylation reactivity.

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-x0h4m-v2
D O I: 10.26434/chemrxiv-2021-x0h4m-v2 [opens in a new tab]

Funding

Mitacs
Research Training Award
Natural Sciences and Engineering Research Council of Canada
Discovery Grant

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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