Cambridge Open Engage home
What is Cambridge Open Engage?
How to Submit
Browse
About
News [opens in a new tab]

Mild and Chemoselective Phosphorylation of Alcohols Using a PSI-Reagent

19 August 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the PSI-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to access.

Keywords

phosphorylation
phosphorus
P(V)
organic methodology

Supplementary materials

Title
Description
Actions
Title
Supporting information
Description
copies of spectra, characterization, and procedures
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.

Now Published

Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent [opens in a new tab]
Michał Ociepa, Kyle W. Knouse, David He, Julien C. Vantourout, Dillon T. Flood, Natalia M. Padial, Jason S. Chen, Brittany B. Sanchez, Emily J. Sturgell, Bin Zheng, Shenjie Qiu, Michael A. Schmidt, Martin D. Eastgate, Phil S. Baran journal article
Organic Letters , Volume 23, Issue 24
Online publication date: Sep 09, 2021

Version History

Aug 19, 2021 Version 1

Metrics

2,926
2,308
0
Views
Downloads
Citations

License

CC logo
CC
BY logo
BY
The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-4ksng
D O I: 10.26434/chemrxiv-2021-4ksng [opens in a new tab]

Funding

National Institutes of Health
GM-118176

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

Share