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Mild and Chemoselective Phosphorylation of Alcohols Using a PSI-Reagent

19 August 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

An operationally simple, scalable, and chemoselective method for the direct phosphorylation of alcohols using a P(V)-approach based on the PSI-reagent platform is disclosed. The method features a broad substrate scope of utility in both simple and complex settings and provides access to valuable phosphorylated alcohols that would be otherwise difficult to access.

Keywords

phosphorylation
phosphorus
P(V)
organic methodology

Supplementary materials

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Now Published

Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent [opens in a new tab]
Michał Ociepa, Kyle W. Knouse, David He, Julien C. Vantourout, Dillon T. Flood, Natalia M. Padial, Jason S. Chen, Brittany B. Sanchez, Emily J. Sturgell, Bin Zheng, Shenjie Qiu, Michael A. Schmidt, Martin D. Eastgate, Phil S. Baran journal article
Organic Letters , Volume 23, Issue 24
Online publication date: Sep 09, 2021

Version History

Aug 19, 2021 Version 1

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The content is available under CC BY 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-4ksng
D O I: 10.26434/chemrxiv-2021-4ksng [opens in a new tab]

Funding

National Institutes of Health
GM-118176

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) declare that they have sought and gained approval from the relevant ethics committee/IRB for this research and its publication.

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