Imidazole Promoted Efficient Anomerization of β-D-Glucose Pentaacetate in Solid State and Reaction Mechanism

09 August 2021, Version 4
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Anomerization of glycosides was rarely performed under basic condition. Here an imidazole promoted anomerization of β-D-glucose pentaacetate in solid state at room temperature was discovered. This unprecedent anomerization in solid state occurred after simple mixing and reaction proceeded continuously to full conversion without stirring or mechanomixing. Current understanding of reaction mechanism involved with inter/intramolecular acyl transfer promoted by two imidazole in concerted manner may promote discovery of more new transformations of glucosides in solid state.

Keywords

Imidazole
Anomerization
Basic condition
hydrogen bonding network
solid state

Supplementary materials

Title
Description
Actions
Title
spportinginfromation-2021 V1
Description
updated supporting information.
Actions

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