Fidelity of Robotic Chemical Operations of Homogenous and Heterogeneous Reactions

Authors

  • Guoqiang Wang Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE ,
  • Bo Xin Nanjing University & School of Management and Engineering & Department of Control and Systems Engineering ,
  • Gaobo Wang Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE ,
  • Yong Zhang Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE ,
  • Yunwen Lu Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE ,
  • Lin Guo Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE ,
  • Shuhua Li Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE ,
  • Chunlin Chen Nanjing University & School of Management and Engineering & Department of Control and Systems Engineering ,
  • Xu Cheng Nanjing University & School of Chemistry and Chemical Engineering & Jiangsu Key Laboratory of Advanced Organic Materials ,
  • Jing Ma Nanjing University & School of Chemistry and Chemical Engineering & Key Laboratory of Mesoscopic Chemistry of MOE

Abstract

Chemical synthesis always involves laborious and time-consuming operations. Autonomous chemical synthesis systems can liberate experimentalists from those routine tasks, but the design of automatic chemical reaction machines is of great challenge. We describe herein the development of a real-life automatic chemical operation platform by using a coordinated multi-robot system with artificial intelligence and machine learning methods. The capacities of this platform were demonstrated by its application in condensation reaction of 2,4-dinitrophenyldrazine with formaldehyde, and automatic catalyst evaluation of a heterogeneous aza Diels-Alder reaction, suggesting the designed machine is applicable to both homogenous and heterogeneous chemical reactions. Besides, the excellent repeatability and reproducibility of robotic tests on these two model reactions indicate the great promise of massive transfer of manual to automatic operation.

Content

Supplementary material

Fidelity of Robotic Chemical Operations of Homogenous and Heterogeneous Reactions
Supporting Information
Fidelity of Robotic Chemical Operations of Homogenous and Heterogeneous Reactions
video file for robotic chemical operation