Biological and Medicinal Chemistry

Synthetic Studies on the Indane SHIP1 Agonist AQX-1125.



A new synthetic route to the SHIP1 agonist AQX-1125 has been developed. This sequence utilizes a hydroxy-acid intermediate which allows for ready differentiation of the C6 and C7 positions. The role of the C17 alkene in the biological activity of the system is also investigated, and this functional group is not required for SHIP1 agonist activity.


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Supplementary material

Thumbnail image of SI-AQX1125-opt.pdf
Experimental procedures, new compound characterization data, and NMR spectra.