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Synthetic Studies on the Indane SHIP1 Agonist AQX-1125.

22 July 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A new synthetic route to the SHIP1 agonist AQX-1125 has been developed. This sequence utilizes a hydroxy-acid intermediate which allows for ready differentiation of the C6 and C7 positions. The role of the C17 alkene in the biological activity of the system is also investigated, and this functional group is not required for SHIP1 agonist activity.

Keywords

steroid
SHIP1
agonist
indane
synthesis

Supplementary materials

Title
Description
Actions
Title
AQXpaper-SI
Description
Experimental procedures, new compound characterization data, and NMR spectra.
Actions

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Version History

Jul 22, 2021 Version 1

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License

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv-2021-vdnql
D O I: 10.26434/chemrxiv-2021-vdnql [opens in a new tab]

Funding

National Institute on Aging
RF1AG059717
National Science Foundation
CHE1659775

Author’s competing interest statement

S.D., S. F-D., W.G.K. and J.D.C. have patents on small molecules targeting of SHIP1 and SHIP2 in disease. The other authors have no conflicts to disclose.

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content

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