Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization–Hydroboration of Unactivated Alkenes

12 July 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp3)–H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.

Keywords

Alkene Isomerization
Directing Group
Tungsten
Hydroboration
Chain-Walking
Organoboron

Supplementary materials

Title
Description
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Title
Supporting Info
Description
Experimental Procedures, Analytical Data, and Copies of NMR Spectra
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Title
2b.cif
Description
Crystallographic Information File - Compound 2b
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2i.cif
Description
Crystallographic Information File - Compound 2i
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2n.cif
Description
Crystallographic Information File - Compound 2n
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Title
3b.cif
Description
Crystallographic Information File - Compound 3b
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