Palladium-Catalyzed intramolecular Cyclization of ‘2-bromo-1,5-
di-ene-7-yne’System: A Versatile Route to the Poly-ene
Substituted Cyclohexenols

Jayanta Kumar Ray; Sunanda Paul; Raju Singha

doi:10.26434/chemrxiv-2021-5cqps

Materials Science

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Palladium-Catalyzed intramolecular Cyclization of ‘2-bromo-1,5- di-ene-7-yne’System: A Versatile Route to the Poly-ene Substituted Cyclohexenols

22 June 2021, Version 1

Working Paper

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This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A general and efficient methodology has been developed for the synthesis of substituted cyclohexenol system with conjugated bis-exocyclic diene via Pd-catalyzed intramolecular 6-exo-dig cyclization of ‘ene-yne’ moiety. This method is straight forward and high yielding.

Keywords

Pd catalyzed reactions

organometallic

Coupling reaction

organic synthesis

Substituted Cyclohexenols

intramolecular Cyclization

poly-ene

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Version History

Jun 22, 2021 Version 1

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The content is available under CC BY NC ND 4.0

DOI

10.26434/chemrxiv-2021-5cqps

Funding

DST

CSIR-Central Scientific Instruments Organisation

Author’s competing interest statement

The author(s) have declared they have no conflict of interest with regard to this content

Ethics

The author(s) have declared ethics committee/IRB approval is not relevant to this content