Palladium-Catalyzed intramolecular Cyclization of ‘2-bromo-1,5- di-ene-7-yne’System: A Versatile Route to the Poly-ene Substituted Cyclohexenols

22 June 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


A general and efficient methodology has been developed for the synthesis of substituted cyclohexenol system with conjugated bis-exocyclic diene via Pd-catalyzed intramolecular 6-exo-dig cyclization of ‘ene-yne’ moiety. This method is straight forward and high yielding.


Pd catalyzed reactions
Coupling reaction
organic synthesis
Substituted Cyclohexenols
intramolecular Cyclization


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