Organic Chemistry

Transition Metal Free Sandmeyer-Type Reductive Disulfuration of Anilines

Xi Wang College of Chemistry and Chemical Engineering, Hunan University

Abstract

A transition metal/ligand free disulfuration of anilines with disulfur transfer reagents (dithiosulfonate or tetrasulfide) is reported herein. The reaction, which can be considered as a reductive disulfuration variation of the classic Sandmeyer reaction, is performed under mild conditions and exhibits broad scope across aniline substrate and disulfur transfer reagent classes. The gram-scale synthesis of disulfides is successfully achieved through this method, rendering the approach highly valuable.

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Supplementary material

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SI 09