Organic Chemistry

Transition Metal Free Sandmeyer-Type Reductive Disulfuration of Anilines

Xi Wang College of Chemistry and Chemical Engineering, Hunan University


A transition metal/ligand free disulfuration of anilines with disulfur transfer reagents (dithiosulfonate or tetrasulfide) is reported herein. The reaction, which can be considered as a reductive disulfuration variation of the classic Sandmeyer reaction, is performed under mild conditions and exhibits broad scope across aniline substrate and disulfur transfer reagent classes. The gram-scale synthesis of disulfides is successfully achieved through this method, rendering the approach highly valuable.


Thumbnail image of preview.pdf
download asset preview.pdf 0.18 MB [opens in a new tab]

Supplementary material

Thumbnail image of SI 09.pdf
download asset SI 09.pdf 7 MB [opens in a new tab]
SI 09