Transition Metal Free Sandmeyer-Type Reductive Disulfuration of Anilines

28 May 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A transition metal/ligand free disulfuration of anilines with disulfur transfer reagents (dithiosulfonate or tetrasulfide) is reported herein. The reaction, which can be considered as a reductive disulfuration variation of the classic Sandmeyer reaction, is performed under mild conditions and exhibits broad scope across aniline substrate and disulfur transfer reagent classes. The gram-scale synthesis of disulfides is successfully achieved through this method, rendering the approach highly valuable.

Keywords

Sandmeyer-Type Reaction
diazonium salts
radical
disulfuration
reductive coupling

Supplementary materials

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Description
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Title
SI 09
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