Abstract
Highly stereoselective synthesis of tetralin-fused spirooxindoles with two contiguous
stereogenic centers. In the present reaction, not only [1,5]-hydride shift/cyclization process, but
also replacemnt of nitrogen atom to oxygen atom ocurred smoothly to give target structure with
hydroxy grop in good chemical yields with good to excellent diastereoselectivities (up to d.r. =
>20:1). Investigation of the reaction mechanism suggested that this “atom-replacement” event
ocurred via the iminium cation intermediates.
Supplementary materials
Title
SI
Description
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