Rh2(II)-Catalyzed Intermolecular N-Aryl Aziridination of Olefins using Nonactivated N-Atom Precursors

24 May 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

The development of the first intermolecular Rh2(II)-catalyzed aziridination of di-, tri-, or tetraubstituted olefins using aryl- or heteroaryl amines as nonactivated N-atom precursors and an iodine(III) reagent as the stoichiometric oxidant is reported. The Rh2(II)-catalyzed N-atom transfer to the olefin is stereospecific, chemo- and diastereoselective to produce the N-aryl aziridine as the only amination product.

Keywords

aziridination reaction
aziridination catalyst
nonactivated amines
rhodium nitrene

Supplementary materials

Title
Description
Actions
Title
aziridine 15p
Description
Actions
Title
aziridine 15l
Description
Actions
Title
SI aziridination
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.