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Abstract
The literature is with a wide variety of against a plethora of . This seminal library is used to inspire chemists to improve them using chemical synthesis. However, their optimization via chemical synthesis is a difficult task which takes time without the guarantee of final success. We show here that chemistry, the use of first and second coordination spheres and the displacement of indicators united within a protein cavity offers an easy-to-assemble bio-chemical sensor. It consists only of commercial chemicals. This sensor is highly modular, cheap and . Its X-ray structure reveals the composition of its active site. This allows to design it rationally for the recognition of dopamine with the naked eye. Our bio-sensor therefore resembles a biological receptor for the recognition of neurotransmitters. Its immediate high adaptability and ability to be evolved can be useful for the selective detection of a wide variety of going from small molecules to microorganisms. This discovery therefore makes it possible to dream of new biotechnological or new applications.
