Marc MAUDUIT Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226
The first continuous flow Z-selective olefin metathesis process is reported. Key to realizing this process was the adequate choice of stereoselective catalysts combined with the design of an appropriate continuous reactor setup. The designed continuous process permits various self-, cross- and macro-ring-closing- metathesis reactions, delivering products in high selectivity and short residence times. This technique is exemplified by direct application to the preparation of a range of pheromones and macrocyclic odorant molecules and culminates in a telescoped Z-selective cross-metathesis/Dieckmann cyclisation sequence to access (Z)-Civetone, incorporating a serial array of continually stirred tank reactors.
download asset CFLOW-Z-OM ChemRxiv.pdf 1 MB [opens in a new tab] cloud_download
pdf : 1 MB
download asset SI_CFLOW-OM ChemRxiv.pdf 8 MB [opens in a new tab] cloud_download
pdf : 8 MB
SI CFLOW-OM ChemRxiv