Working Paper
Authors
- Jennifer Morvan ,
- Tom McBride ,
- Idriss Curbet ,
- Sophie Colombel-Rouen ,
- Thierry Roisnel ,
- Christophe Crévisy ,
- Duncan L. Browne ,
- Marc MAUDUIT
Univ Rennes, Ecole Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226
Abstract
The first
continuous flow Z-selective olefin metathesis process is reported. Key to
realizing this process was the adequate choice of stereoselective catalysts combined
with the design of an appropriate continuous reactor setup. The designed
continuous process permits various self-, cross- and macro-ring-closing-
metathesis reactions, delivering products in high selectivity and short
residence times. This technique is exemplified by direct application to the
preparation of a range of pheromones and macrocyclic odorant molecules and
culminates in a telescoped Z-selective cross-metathesis/Dieckmann cyclisation
sequence to access (Z)-Civetone, incorporating a serial array of continually
stirred tank reactors.
Content

Supplementary material

SI CFLOW-OM ChemRxiv