Biological and Medicinal Chemistry

Cu-Based Turn-on Fluorescent Sensors for Cu-rich Amyloid β Aggregates

Liviu M. Mirica University of Illinois at Urbana-Champaign

Abstract

Protein misfolding and metal dishomeostasis are two key
pathological factors of Alzheimer’s disease. Previous studies have showed that Cu‐mediated Aβ aggregation pathways lead to formation of neurotoxic Aβ oligomers. Herein, we reported a series of picolinic acid‐based Cu‐activatable sensors, which can be used for the fluorescence imaging of Cu‐rich Aβ aggregates.

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Content

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Supplementary material

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