Chitosan Nanocrystals Synthesis via Aging and Application Towards Alginate Hydrogels for Sustainable Drug Release

Tony Jin; Tracy Liu; Shuaibing Jiang; Vladimir Michaelis; David Kurdyla; Brittney A. Klein; Edmond Lam; Jianyu Liu; Audrey Moores

doi:10.26434/chemrxiv.14541909.v1

Working Paper

Abstract

In this article, we demonstrate a new and clean method for the fabrication of chitosan nanocrystals relying on aging. We provide metrics to showcase the greeness of this method. We are then using these materials as building block to fabricate alginate hydrogels, and demonstrated that they have superior properties for gelation and drug release.

Version notes

This is the first version released to the public

Content

Supplementary material

210426 Supp Info TJ

210505 Aging Draft TJ

Version History

May 07, 2021 Version 1

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337

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License

The content is available under CC BY NC ND 4.0 License CreativeCommons.org

DOI

10.26434/chemrxiv.14541909.v1

Funding

Natural Sciences and Engineering Research Council

N/A

Natural Sciences and Engineering Research Council

https://app.dimensions.ai/details/grant/grant.8649927

Fonds de Recherche du Québec – Nature et technologies

164037

Centre in Green Chemistry and Catalysis (CGCC)

https://app.dimensions.ai/details/grant/grant.4648532

Canada Research Chairs

Canada Foundation for Innovation

McGill University

National Research Council - Industrial Biotechnology

Author’s competing interest statement

No conflicts

Keywords

Chitin

chitosan

Nanocrystals

Biomass

Alginate

Nanocrystal

Mechanochemistry

Aging

nanomaterial applications

hydrogels

alginate

Publication

This content is an early or alternative research output and has not been peer-reviewed at the time of posting.