Abstract
Here we report a study
on cyclohexanohemicucurbit[8]uril (cycHC[8]) binding of sulfur-, oxygen- and
nitrogen-containing heterocycles in both solid state and solution, which is
investigated by single crystal X-ray diffraction, NMR spectroscopy, isothermal
titration calorimetry, and thermogravimetry. Potential guests include
environmental pollutants, hazardous compounds, and bioactive substances. We
found that cycHC[8] encapsulates five- and six-membered sulfur- and
oxygen-containing unsubstituted heterocycles and can be used as a selective
sorption material for the extraction of sulfur-heterocycles from water. Both
cycHC[6] and cycHC[8] can remove a substituted heterocycle, α-lipoic acid, from
an aqueous solution via the formation of an external complex. The results show
that cycHC[n] is a promising reusable sorbent material with the
potential to be employed in molecular recognition and highly specific
solid-phase extraction of sulfur-heterocycles.
Supplementary materials
Title
cycHC SPE ChemRxiv SI
Description
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