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Enantioselective Addition of Pyrazoles to Dienes

28 April 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd(0)-catalyzed ligand-to?ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and provides a breakthrough in hydrofunctionalization of dienes.

Keywords

pyrazole
1,3-diene
hydroamination
Pd catalysis
enantioselective

Supplementary materials

Title
Description
Actions
Title
Dong Pyrazole Hydroamination SI
Description
Actions

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Version History

Apr 28, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14489379.v1
D O I: 10.26434/chemrxiv.14489379.v1 [opens in a new tab]

Author’s competing interest statement

No conflict of interest

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