Theoretical and Computational Chemistry

DrugEx v2: De Novo Design of Drug Molecule by Pareto-based Multi-Objective Reinforcement Learning in Polypharmacology

Abstract

In polypharmacology, ideal drugs are required to bind to multiple specific targets to enhance efficacy or to reduce resistance formation. Although deep learning has achieved breakthrough in drug discovery, most of its applications only focus on a single drug target to generate drug-like active molecules in spite of the reality that drug molecules often interact with more than one target which can have desired (polypharmacology) or undesired (toxicity) effects. In a previous study we proposed a new method named DrugEx that integrates an exploration strategy into RNN-based reinforcement learning to improve the diversity of the generated molecules. Here, we extended our DrugEx algorithm with multi-objective optimization to generate drug molecules towards more than one specific target (two adenosine receptors, A1AR and A2AAR, and the potassium ion channel hERG in this study). In our model, we applied an RNN as the agent and machine learning predictors as the environment, both of which were pre-trained in advance and then interplayed under the reinforcement learning framework. The concept of evolutionary algorithms was merged into our method such that crossover and mutation operations were implemented by the same deep learning model as the agent. During the training loop, the agent generates a batch of SMILES-based molecules. Subsequently scores for all objectives provided by the environment are used for constructing Pareto ranks of the generated molecules with non-dominated sorting and Tanimoto-based crowding distance algorithms. Here, we adopted GPU acceleration to speed up the process of Pareto optimization. The final reward of each molecule is calculated based on the Pareto ranking with the ranking selection algorithm. The agent is trained under the guidance of the reward to make sure it can generate more desired molecules after convergence of the training process. All in all we demonstrate generation of compounds with a diverse predicted selectivity profile toward multiple targets, offering the potential of high efficacy and lower toxicity.

Version notes

pre-print version to Journal of Cheminformatics v1.0

Content

Thumbnail image of 20210407-Manuscript-LiuX.pdf

Supplementary material

Thumbnail image of fig_1.tiff
fig 1
Thumbnail image of fig_2.tiff
fig 2
Thumbnail image of fig_3.tiff
fig 3
Thumbnail image of fig_4AB.tiff
fig 4AB
Thumbnail image of fig_4CE.tiff
fig 4CE
Thumbnail image of fig_5.tiff
fig 5
Thumbnail image of fig_6.tiff
fig 6
Thumbnail image of fig_7A.tiff
fig 7A
Thumbnail image of fig_7B.tiff
fig 7B
Thumbnail image of fig_1.tiff
fig 1
Thumbnail image of fig_1.tiff
fig 1
Thumbnail image of fig_2.tiff
fig 2
Thumbnail image of fig_3.tiff
fig 3
Thumbnail image of fig_4AB.tiff
fig 4AB
Thumbnail image of fig_4CE.tiff
fig 4CE
Thumbnail image of fig_5.tiff
fig 5
Thumbnail image of fig_6.tiff
fig 6
Thumbnail image of fig_7A.tiff
fig 7A
Thumbnail image of fig_7B.tiff
fig 7B