Are Rate and Selectivity Correlated in Iridium-Catalysed Hydrogen Isotope Exchange Reactions?

21 April 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Herein we examine the relationship between reaction rate and reaction selectivity in iridium-catalysed hydrogen isotope
exchange (HIE) reactions directed by Lewis basic functional groups. We have recently develped a directing group scale that allows semi-quantitative predictions of Lewis base directed selectivity in HIE, formally ranking ‘relative rates’ determined from a structured set of competition experiments. Here, we show that selectivity and rate are in fact not correlated, but that different types of behaviour emerge in competition experiments and that the observed behaviour can be predicted from our established selectivity scale.

Keywords

iridium
hydrogen isotope exchange
C-H activation

Supplementary materials

Title
Description
Actions
Title
HIE Profiles-Timofeeva ESI
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.