Stirring Peptide Synthesis to a New Level of Efficiency

13 April 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In this work, a new setup that relies on fast stirring and heating was used to increase the diffusion of both reagents and solid support. we show that the combination of fast mixing and elevated temperature enables the acceleration of solid-phase peptide synthesis without using a large excess of reagents, providing a greener and accessible alternative to the state-of-the-art.

Keywords

SPPS
Diffusion
Fick's second law
Green Chemistry

Supplementary materials

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HTFSPS for chemrxiv SI
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