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A Platform for Alkene Carbofunctionalization with Diverse Nucleophiles

26 March 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented. A range of substituted alkenes are functionalized with α-bromo carbonyl electrophiles and nitrogen, oxygen, and carbon nucleophiles. Mechanistic findings support the intermediacy of a cyclic oxocarbenium ion.

Keywords

Copper
Carboamination
Alkene Functionalization

Supplementary materials

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Version History

Mar 26, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.14308421.v1
D O I: 10.26434/chemrxiv.14308421.v1 [opens in a new tab]

Funding

NIH NIGMS
The Welch Foundation
Novartis
Eli Lilly and Co.

Author’s competing interest statement

The authors declare no competing financial interests.

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