Organic Chemistry

A Platform for Alkene Carbofunctionalization with Diverse Nucleophiles



A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented. A range of substituted alkenes are functionalized with α-bromo carbonyl electrophiles and nitrogen, oxygen, and carbon nucleophiles. Mechanistic findings support the intermediacy of a cyclic oxocarbenium ion.


Thumbnail image of ChemRxiv Manuscript.pdf

Supplementary material

Thumbnail image of ChemRxiv SI.pdf
ChemRxiv SI