A Platform for Alkene Carbofunctionalization with Diverse Nucleophiles

26 March 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A general system achieving three-component intermolecular carbofunctionalization of alkenes is presented. A range of substituted alkenes are functionalized with α-bromo carbonyl electrophiles and nitrogen, oxygen, and carbon nucleophiles. Mechanistic findings support the intermediacy of a cyclic oxocarbenium ion.

Keywords

Copper
Carboamination
Alkene Functionalization

Supplementary materials

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