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Abstract
Our work demonstrates the ability to perform high spatial resolution imaging mass spectrometry (IMS) using silicon nanopost arrays (NAPA), a matrix-free laser desorption ionization (LDI) substrate, for multiple classes of neutral lipids from biological tissue sections.
Utilized trapped ion-mobility spectrometry (TIMS) coupled with IMS to enhance the molecular coverage of detected neutral lipid species, as well as for differentiating neutral lipid isomeric species spatial distributions.
