Molecular Mapping of Neutral Lipids using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry

16 March 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Our work demonstrates the ability to perform high spatial resolution imaging mass spectrometry (IMS) using silicon nanopost arrays (NAPA), a matrix-free laser desorption ionization (LDI) substrate, for multiple classes of neutral lipids from biological tissue sections.

Utilized trapped ion-mobility spectrometry (TIMS) coupled with IMS to enhance the molecular coverage of detected neutral lipid species, as well as for differentiating neutral lipid isomeric species spatial distributions.


mass spectrometry
ion mobility
laser desorption ionization


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