Organic Chemistry

Electrochemical Borylation of Carboxylic Acids


A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Version notes

version 1.0


Thumbnail image of Echem Borylation Text Submission.pdf

Supplementary material

Thumbnail image of SI Electrochemical Borylation Final.pdf
SI Electrochemical Borylation Final