Organic Chemistry

Electrochemical Borylation of Carboxylic Acids

Abstract

A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

Version notes

version 1.0

Content

Thumbnail image of Echem Borylation Text Submission.pdf

Supplementary material

Thumbnail image of SI Electrochemical Borylation Final.pdf
SI Electrochemical Borylation Final