The Interaction of Chondroitin Sulfate with a Lipid Monolayer Observed by Using Nonlinear Vibrational Spectroscopy

Gergo Peter Szekeres; Szilvia Krekic; Rebecca L. Miller; Mark Mero; Kevin Pagel; Zsuzsanna Heiner

doi:10.26434/chemrxiv.14192879.v1

Physical Chemistry

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The Interaction of Chondroitin Sulfate with a Lipid Monolayer Observed by Using Nonlinear Vibrational Spectroscopy

Working Paper

Gergo Peter Szekeres ,
Szilvia Krekic ,
Rebecca L. Miller ,
Mark Mero ,
Kevin Pagel ,
Zsuzsanna Heiner School of Analytical Sciences Adlershof, Humboldt-Universität zu Berlin

Abstract

We present the first vibrational sum-frequency generation spectroscopic study of chondroitin sulfate (CS) interacting with dipalmitoyl phosphatidylcholine (DPPC) at the air-liquid interface. In the presence of Ca²⁺ and CS, the DPPC headgroups reoriented, while the tail orientations remained mostly unchanged. The results further suggest a chiral secondary structure for CS.