Physical Chemistry

The Interaction of Chondroitin Sulfate with a Lipid Monolayer Observed by Using Nonlinear Vibrational Spectroscopy



We present the first vibrational sum-frequency generation spectroscopic study of chondroitin sulfate (CS) interacting with dipalmitoyl phosphatidylcholine (DPPC) at the air-liquid interface. In the presence of Ca2+ and CS, the DPPC headgroups reoriented, while the tail orientations remained mostly unchanged. The results further suggest a chiral secondary structure for CS.


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Supplementary material

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GPSZetal 20200310 SI