Graphene-Oxide Based Fluorescent DNA Aptasensor for Liver Cancer Diagnosis and Therapy

10 March 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Graphene-oxide based fluorescent DNA aptasensors for the in vivo application remain a challenging task. We demonstrate for the first time such a nanomaterial for in vivo diagnosis and therapy of liver tumor with good biocompatibility and high selectivity. This DNA nanomaterial comprising of DNA tetrahedron and aptamers, aggregation-induced emission luminogen (AIEgens) and antitumor drug doxorubicin, is fabricated and attached on GO surface. Additionally, this GO-based fluorescent DNA nanodevice is also constructed by using microfluidic chip for liver tumor cell screening.

Keywords

DNA aptamer
DNA tetrahedron
aggregation-induced emission
cell screening
cancer theranostics

Supplementary materials

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Manuscript 20210308-Ke净版
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