Prediction of Dissociation Constant in Protein-Ligand Interaction

In protein-ligand interactions, such as antigen-antibody interactions and hormone-receptor interactions, a correlation between the equilibrium dissociation constant K_D and the reduced mass of the protein and ligand was found. The correlation of dissociation constants as pK_D (-logK_D) between literature values and predicted values was confirmed in high coefficient of determination R² over 0.98.