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Thiol-methylsulfone-based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-methylsulfone Substrate for Fine-tunable Gelation Rate and Improved Stability

Abstract

We present novel thiol-methylsulfone hydrogels for cell encapsulation applications. The reactivity of the methylsulfonyl reactive partner has been optimized to improve the properties of the derived hydrogels for cell encapsulation.

Version notes

First version

Content

Supplementary material

SuppInfo PaezJI

Version History

Feb 26, 2021 Version 1

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The content is available under CC BY NC 4.0 License CreativeCommons.org [opens in a new tab]

DOI

10.26434/chemrxiv.14115404.v1
D O I: 10.26434/chemrxiv.14115404.v1 [opens in a new tab]

Funding

Deutsche Forschungsgemeinschaft (DFG, Project no. 422041745)
Deutscher Akademischer Austauschdienst (DAAD, Exchange Internship Program)
European Union’s Horizon 2020 research and innovation programme under the FET PROACTIVE grant agreement no. 731957 (Mechano-Control)

Author’s competing interest statement

No conflict of interest

Keywords

thiol-arylmethylsulfone
cell encapsulation
PEG hydrogels
water-based crosslinking reactions
gel stability
gelation kinetics

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This content is an early or alternative research output and has not been peer-reviewed at the time of posting.