Analytical Chemistry

NMR for Mixture Analysis: Concentration Ordered Spectroscopy

Bin Yuan Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences


A novel approach, concentration ordered NMR spectroscopy (CORDY), is being proposed based on the principle that the ratio of NMR peak area to its associated number of spins is proportional to the concentration of the assigned compound.CORDY generates a pseudo 2-dimensional NMR spectrum with chemical shifts in one axis and concentrations in the other, resulting both in separation and quantitation of components in complex samples. The method was validated by applying on three samples. It was demonstrated that CORDY could successfully provide separation up to two orders of magnitude in concentration dimension, for the samples used in current study.


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Supplementary material

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CORDY ACS SI-2021 221
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