Maurice Michel Science for Life Laboratory, Department of Oncology and Pathology, Karolinska Institutet
Photochemistry is a fast growing research field and many transformations previously not accessible to chemists now have become part of an ever growing standard repertoire. The limiting factors for a photo reactor system however is the possibility to perform stirring, removal of excess heat and the irradiation with UV or visible light – all that within a secure surrounding. Systems for starters may be as expensive as several thousand Euro. Here we design and assemble a LED photo reactor using scrap and standard materials, only spending less than 30 € for a LED. The system may be adjusted to any required wave length and its assembly is shown for the use of a 400 nm wave length lamp. To demonstrate its application, we then exemplarily use the reactor in the removal of a photo labile protection group during the synthesis of a SARS-CoV-2 spike protein glyco peptide.
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