Working Paper
Authors
- Fuzhuo Li ,
- Li-Cheng Yang ,
- Jingyang Zhang ,
- Jason Chen ,
- Hans Renata
The Scripps Research Institute
Abstract
We report a biocatalytic transamination method to prepare a broad range of b-branched a-amino acids that proceeds with high diastereo- and enantioselectivity. Mechanistic studies show that the transformation proceeds through a dynamic kinetic resolution process that is unique to the optimal enzyme. To highlight its utility and practicality, the biocatalytic reaction is applied to the synthesis of several cyclic fragments and in the first total synthesis of jomthonic acid A.
Content

Supplementary material

ArAT SI combined 020321