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Nickel-Catalyzed Benzylic Alkynylation: Migratory Hydroalkynylation and Enantioselective Hydroalkynylation of Olefins with Bromoalkynes

02 February 2021, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A nickel-hydride catalyzed reductive migratory hydroalkynylation of olefins with bromoalkynes that delivers the corresponding benzylic alkynylation products in high yield and with excellent regioselectivity has been developed. Catalytic enantioselective hydroalkynylation of styrenes has been realized using a simple chiral PyrOx ligand. The obtained enantioenriched benzylic alkynes are versatile synthetic intermediates and can be readily transformed into synthetically useful chiral synthons

Keywords

Asymmetric Catalysis
hydroalkynylation
Nickel Catalysis
Regioselectivity
alkenes
nickel hydride

Supplementary materials

Title
Description
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Title
Jiang Asymmetric hydroalkynylation SI
Description
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Version History

Feb 02, 2021 Version 1

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13681432.v1
D O I: 10.26434/chemrxiv.13681432.v1 [opens in a new tab]

Funding

National natural Science Foudation of China 21822105
National natural Science Foudation of China 21772087
National natural Science Foudation of Jiangsu Province (BK20190281, BK20201245)

Author’s competing interest statement

The authors declare no competing financial interest.

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