Correlation Between Yield and Reduced Mass of Raw Materials in Enzymatic Reactions

Correlation between the yield in the enzymatic reaction and the molecular weight of the substrate as an approximation of the reduced mass of the raw materials was clarified. The correlation was expressed by the same regression equation as in general organic chemical reactions. The coefficient of the regression equation to distinguish between intramolecular and intermolecular reactions were better when the values for intramolecular reactions were used in the plot of literature yields versus predicted yields. It was also found that the adjustment of the reduced mass by the number of rotatable bonds was not necessary and was found to be a good representation of the characteristics of the enzymatic reaction.