Copper-Free One-Pot Sonogashira-Type Coupling for the Efficient Preparation of Symmetric Diarylalkyne Ligands for Metal-Organic Cages

25 January 2021, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


Bipyridine- and benzimidazole-based ligands for the self-assembly of Co4L6 cages were synthesised in short reaction times and high isolated yields directly from aryl halide precursors using a copper-free one-pot Sonogashira-type coupling. This one-pot method circumvents the often time-consuming and challenging ligand synthesis for the preparation and application of cages.


supramolecular chemistry
metal-organic cage
Sonogashira-type couplings
Ligand Synthesis

Supplementary materials

21.1.22 Copper Free One Pot Sonogashira Type Coupling SI Chemrxiv


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