Working Paper
Authors
- Steven T. G. Street ,
- pablo Peñalver ,
- Michael O'Hagan ,
- Gregory J. Hollingworth ,
- Juan Carlos Morales ,
- M. Carmen Galan
School of Chemistry, University of Bristol
Abstract
A facile imide coupling strategy for the one-step preparation of G‑quadruplex ligands with varied core chemistries is described. The G‑quadruplex stabilization, anticancer and antiparasitic activity of a library of nine compounds was examined, identifying a nanomolar inhibitor of T. brucei with 78‑fold selectivity over MRC5 cells, and strong stabilization of G‑quadruplex nucleic acids.
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Supplementary material

Core Diversification SI v0.8