The Use of UiO-Type MOFs in Vapour Phase Soai Reactions

31 December 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We report a novel vapour phase procedure to perform the Soai reaction in an absolute asymmetric synthesis fashion: the substrate is confined in the pores of the UiO-type MOFs, and vapour phase reactions with Zn(i-Pr)2 are performed in a sealed environment, Different MOFs lead to different outcomes in terms of enantiomeric excess, handedness of the product and reaction rate. This is one of the first examples of absolute asymmetric synthesis performed inside a MOF.




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