Total Synthesis of the Alleged Structure of Crenarchaeol Enables Structure Revision

23 December 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

This study describes the first asymmetric total synthesis of the proposed structure of the archaeal membrane-spanning tetraether lipid crenarchaeol. The synthetic material was compared by NMR and GC-MS analysis with natural crenarchaeol. Detailed NMR analysis ultimately enabled the structure revision of crenarchaeol, identifying one out of 22 sterecenters to be inverted.

Keywords

Total Synthesis
Structure Revision
archaeal GDGT
Asymmetric Synthesis

Supplementary materials

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Supporting Information HRMS spectra Appendix
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Supporting Information NMR spectra Appendix
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Supporting Information Procedures
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