Abstract
This study describes the first asymmetric total synthesis of the proposed structure of the archaeal membrane-spanning tetraether lipid crenarchaeol. The synthetic material was compared by NMR and GC-MS analysis with natural crenarchaeol. Detailed NMR analysis ultimately enabled the structure revision of crenarchaeol, identifying one out of 22 sterecenters to be inverted.
Supplementary materials
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Supporting Information HRMS spectra Appendix
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Supporting Information NMR spectra Appendix
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Supporting Information Procedures
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