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A Cost-Effective and Eco-Friendly Way to Dihydroxylate Terminal and Internal Alkenes Using Hydrogen Peroxide/formic Acid

07 December 2020, Version 2
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Abstract In this report, we present a modified dihydroxylation procedure for terminal and internal alkenes under neat conditions using formic acid and hydrogen peroxide. Upon the in situ formation of performic acid, followed by the hydrolysis of hydroxy-formoxy compounds with excess water, we can obtain a series of diols without catalysts and bases.

Keywords

oxidationmodification
Dihydroxylation
Metal-Free Approach

Supplementary materials

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Version History

Dec 07, 2020 Version 2

Version Notes

first version

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13268942.v2
D O I: 10.26434/chemrxiv.13268942.v2 [opens in a new tab]

Funding

Argonne National Laboratory is a U. S. Department of Energy Office of Science laboratory operated by UChicago Argonne, LLC, under contract DE-AC02-06CH11357. The work published is sponsored by DOE EERE Vehicle Technology Office

Author’s competing interest statement

The authors declare no conflict of interest.

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