Organic Chemistry

Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation

Authors

Abstract

Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.

Content

Thumbnail image of ChemRxiv Sulfonation MS 2020 12 05.pdf

Supplementary material

Thumbnail image of ChemRxiv Sulfonation SI 2020 12 05.pdf
ChemRxiv Sulfonation SI 2020 12 05