Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation

07 December 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.

Keywords

sulfonation
biaryl monophosphine
water soluble ligand
ligand

Supplementary materials

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Title
ChemRxiv Sulfonation SI 2020 12 05
Description
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