Organic Chemistry

Double Ligand-Enabled Ni-Catalyzed C-H Alkenylation of Amines with Alkynes

Abstract

A nickel-catalyzed C−H alkenylation of amines with alkynes was developed, providing a series of allylic amines in up to 94% yield. The use of bulky amino protecting group (triisopropylphenylsulfonyl) and double ligands (IPr and PCy3) proved critical to the reaction efficiency.

Content

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Supplementary material

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SI-20201201
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Ni-coupling-20201201