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Double Ligand-Enabled Ni-Catalyzed C-H Alkenylation of Amines with Alkynes

03 December 2020, Version 1
Working Paper
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

A nickel-catalyzed C−H alkenylation of amines with alkynes was developed, providing a series of allylic amines in up to 94% yield. The use of bulky amino protecting group (triisopropylphenylsulfonyl) and double ligands (IPr and PCy3) proved critical to the reaction efficiency.

Keywords

nickel
amine
alkyne
allylic amine
alkenylation

Supplementary materials

Title
Description
Actions
Title
SI-20201201
Description
Actions
Title
Ni-coupling-20201201
Description
Actions

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Version History

Dec 03, 2020 Version 1

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License

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The content is available under CC BY NC ND 4.0 [opens in a new tab]

DOI

10.26434/chemrxiv.13315622.v1
D O I: 10.26434/chemrxiv.13315622.v1 [opens in a new tab]

Funding

the National Natural Science Foundation of China (21672107, 21871145, 21933003, and 91856104)
the Fundamental Research Funds for the Central Universities (63191601)

Author’s competing interest statement

The authors declare no competing financial interests.

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