Hypoxia-activated Probe for NIR Fluorescence and Photoacoustic Dual-mode Tumor Imaging

02 December 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


We rationally designed and synthesized a hypoxia-responsive probe TBTO featuring four diethylamino N-oxide groups that could undergo bioreduction in a hypoxic microenvironment, producing TBT with a typical D-A-D structure. It was demonstrated that TBT possesses NIR fluorescence emission and PA signal generation, benefiting from its both AIE property and a strong TICT effect. In vitro and in vivo assessments revealed the responsiveness of TBTO in a reductive environment and its NIR fluorescence and PA dual-mode imaging ability.


Aggregation-induced emission
Tumor hypoxia
Photoacoustic imaging
Fluorescence imaging


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