Intramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds

01 December 2020, Version 1


Direct oxidative coupling of different inert C-H bonds is the most straightforward and environmentally benign method to construct C-C bonds. In this article, we developed a Pd-catalyzed intramolecular oxidative coupling between unactivated aliphatic and aryl C-H bonds. This chemistry showed great potential to build up fused cyclic scaffolds from linear substrates through oxidative couplings. Privileged chromane and tetralin scaffolds were constructed from readily available linear starting materials in the absence of any organohalides and organometallic partners.


Supplementary materials

Supporting Information-ly1127-3-1128


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