Graphene Reinforced Polyether Ether Ketone Nanocomposites for Bone Repair Applications

27 November 2020, Version 1
This content is a preprint and has not undergone peer review at the time of posting.


To improve the performance of polyether ether ketone matrix (PEEK) in hard tissue repair and replacement applications, we fabricated graphene (G) reinforced PEEK with graded G concentrations (0.1%-5%) through injection molding. The mechanical properties, surface morphology, chemical composition and thermal stability of the composites have been characterized through universal mechanical testing, scanning electron microscopy, contact-angle measurement, transmission electron microscope, X-ray photoelectron spectroscopy, X-ray diffraction and thermal analysis system. The biocompatibility has been assessed in vitro and the bone repair function of the composite implant have been assessed in vivo using a rabbit mandibular bone defect model. Mechanical testing results suggest that the composite samples have compressive moduli similar to that of the natural bone. Although addition of G into PEEK does not significantly influence the composite tensile, flexural or compressive moduli, it can significantly enhance the ductility and toughness of the material. On the other hand, all G-reinforced PEEK implants demonstrated enhanced adhesion and differentiation of rat bone marrow stromal cells (BMSCs), with 5% G-PEEK showing the highest bioactivity among all samples. The in vivo osseointegration data further revealed that 5% G-PEEK has the best effect in promoting osseointegration and bone regeneration, in both early stage and late stage bone re-growth. Study shows that our G-reinforced PEEK-based implants provides a promising strategy for enhancing the performance of future regenerative bone implants.


polyether ether ketone
bone repair


Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.